Molecular group:
Metabolic markers
Molecule/Cell:
Glucocorticoid receptor (GR)
Plasmodium strain:
Plasmodium berghei NK65
pRBC infection titer:
10^4
Mouse genetic background (Con):
C57BL/6J
Experimental treatment group (EG):
dexamethasone (late treatment)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
MA-ARDS (90%)
Pathology (EG):
MA-ARDS (10%)
Parasitemia (EG vs Con):
Increased
Additional phenotypes (EG vs Con):
↓ lung weight 10 days p.i.; ↓ IFN-g and MCP-1, ↑ TNF-a, IL-10, IL-1b and MIP-2 and similar MIF, mGCP-2/LIX, KC and MIG mRNA expression in the lungs 10 days p.i.; the mRNA expression of IP-10 and I-TAC were unsignificantly ↑; ↓ number of macrophages, CD4+ and CD8+ T cells and similar numbers of neutrophils in the lungs 10 days p.i.; ↓ number of CD4+ and CD8+ T cells in the spleen 10 days p.i.; ↓ % of Treg cells in infected spleens
Refs:
Van den Steen et al., 2010, Am J Crit Care Med
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