Molecular group:
Metabolic markers
Molecule/Cell:
Glucocorticoid receptor (GR)/TNF-a
Plasmodium strain:
Plasmodium berghei K173
pRBC infection titer:
10^3
Mouse genetic background (Con):
C57BL/6J
Experimental treatment group (EG):
dexamethasone + rHu-TNF-a (↑ dose)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM
Pathology (EG):
No CM
Parasitemia (EG vs Con):
Decreased on day 7
Additional phenotypes (EG vs Con):
No neurological symptoms (only for combinations with a low dose of dexamethasone (2,5 or 5 mg/mL) and when TNF-a was administered on day 7-8)
Refs:
Curfs et al., 1993, Parasitology
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