Molecular group:
Metabolic markers
Molecule/Cell:
Taurine
Plasmodium strain:
Plasmodium chabaudi (N.I.)
pRBC infection titer:
10^6
Mouse genetic background (Con):
129/SvJ x C57BL/6
Level of backcrossing:
Mixed background (50%)
Experimental treatment group (EG):
Taut -/-
Lethal infection (Con):
10%
Lethal infection (EG):
yes
Pathology (Con):
Anemia
Pathology (EG):
Multiple organ dysfunction
Parasitemia (EG vs Con):
Increased peak
Additional phenotypes (EG vs Con):
All mice died between day 8 and 13 p.i. of MOD (brain, liver, lung and kidney pathology); ↓ circulating taurine levels; similar AST, ALT, bile acid and bilirubin; ↑ plasma ammonia levels; ↑ serum TNF-a and IL-1b; liver: necrotic areas and inflammation; hypertrophic Kuppfer cells with more Hz; no reduction in particle trapping capacity; ↑ IL-1b, TNF-a, IL-6, iNOS, NF-KB, VDR and similar CYP3A11, SULT2B1, UGT1A1, MRP4, Actb mRNA expression
Refs:
Delic et al., 2010, Infect Immun
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