Molecular group:
Metabolic markers
Molecule/Cell:
HMG-CoA reductase
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
5 x 10^5
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
HMG-CoA reductase inhibitor (statins)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (100%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
↓ plasma IFN-g and similar plasma levels of MCP-1 5 days p.i.; similar plasma levels of IL-6 6 days p.i.; dose-dependent ↑ of TNF-a and IL-6 production by TLR2 and TLR4-stimulated peritoneal macrophages
Refs:
Helmers et al., 2009, Am J Trop Med Hyg
Hyperlink: