Molecular group:
Metabolic markers
Molecule/Cell:
Kynurenine-3-hydroxylase
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
N.I.
Mouse genetic background (Con):
C57BL/6J
Experimental treatment group (EG):
kynurenine-3-hydroxylase inhibitor
Lethal infection (Con):
yes
Lethal infection (EG):
none at the end of the observation perion day 21
Pathology (Con):
CM
Pathology (EG):
No CM
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
No neurologic symptoms; prolonged survival (~ 2 weeks); ↓ PA, similar QA and ↑ KA and AA levels in brain; ↑ KA:QA ratio; ↓ MIP-1a in brain
Refs:
Clark et al., 2005, Infect Immun
Hyperlink: