Molecular group:
Metabolic markers
Molecule/Cell:
IDO-1
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
kynurenine-3-hydroxilase inhibitor (i.p. vs p.o.)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (60% i.p. or 75% p.o.)
Parasitemia (EG vs Con):
Decreased (i.p.) or similar (p.o.)
Additional phenotypes (EG vs Con):
No neurologic symptoms; prolonged survival (~ 2 weeks); ↓ brain PA (also ↓ in mice that developed fatal CM, but less pronounced); similar KA and QA levels in brain
Refs:
Miu et al, 2009, Int J Parasitol
Hyperlink: