Molecular group:
Metabolic markers
Molecule/Cell:
IDO-1
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
IDO-1 -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (100%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Similar histopathology; ↓ IDO-2 mRNA expression in brain (also in non-infected animals → IDO-2 in close proximity to IDO-1, and probably partly affected by gene knock out procedure); no ↑ tryptophan dioxygenase (Tdo) mRNA expression in brain; ↓ brain kynurenic acid (KA) (similar t non-infected IDO-1 -/- mice); ↓ brain quinolinic acid (QA) (but only slightly higher than non-infected IDO-1 -/- mice); ↓ brain picolinic acid (PA) (but significantly ↑ than non-infected IDO-1 -/- mice)
Refs:
Miu et al, 2009, Int J Parasitol
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