NADPH oxidase

Molecular group: 
Metabolic markers
Molecule/Cell: 
NADPH oxidase
Plasmodium strain: 
Plasmodium chabaudi adami 556KA
pRBC infection titer: 
10^6
Mouse genetic background (Con): 
C57BL/6
Level of backcrossing: 
Backcrossed for at least 12 generations
Experimental treatment group (EG): 
p47phox-/- (no ROI produced by the NADPH oxidase pathway)
Lethal infection (Con): 
no
Lethal infection (EG): 
no
Pathology (Con): 
N.I.
Pathology (EG): 
N.I.
Parasitemia (EG vs Con): 
Similar
Additional phenotypes (EG vs Con): 
Putative function of ROI was not masked by antibody-mediated immunity as B cell deficient p47phox -/- mice displayed similar parasitemias
Refs: 
Gillman et al., 2004, Infect Immun