Molecular group:
Metabolic markers
Molecule/Cell:
NOS2
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
N.I.
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
NO donor or + NO gas
Lethal infection (Con):
yes
Lethal infection (EG):
20% (at the end of observation day 12)
Pathology (Con):
CM (100%)
Pathology (EG):
CM (20%)
Parasitemia (EG vs Con):
similar
Additional phenotypes (EG vs Con):
No neurological symptoms; restored cGMP brain levels; ↓ plasma IL-18, sCD40 and MMP-9; similar IL-1b, IL-6, IL-10, IFN-g and TIMP-1
Refs:
Gramaglia et al., 2006, Nat Med
Hyperlink: