HO-1

Molecular group: 
Neural or endothelial cell stress/damage/activation markers
Molecule/Cell: 
HO-1
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
10^6 - 10^7
Mouse genetic background (Con): 
DBA/2
Experimental treatment group (EG): 
CO gas
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
ALI (55%) or HP&A
Pathology (EG): 
HP&A
Parasitemia (EG vs Con): 
Similar
Additional phenotypes (EG vs Con): 
↓ mortality from ALI (0% vs 50%); no ↑ in serum VEGF levels; no pulmonary hemorrhages or edema
Refs: 
Epiphanio et al., 2010, PLoS Pathog