Molecular group:
Neural or endothelial cell stress/damage/activation markers
Molecule/Cell:
HO-1
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6 - 10^7
Mouse genetic background (Con):
DBA/2
Experimental treatment group (EG):
CO gas
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
ALI (55%) or HP&A
Pathology (EG):
HP&A
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
↓ mortality from ALI (0% vs 50%); no ↑ in serum VEGF levels; no pulmonary hemorrhages or edema
Refs:
Epiphanio et al., 2010, PLoS Pathog
Hyperlink: