Molecular group:
Neural or endothelial cell stress/damage/activation markers
Molecule/Cell:
HO-1
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^6
Mouse genetic background (Con):
129 Sv x BALB/c
Level of backcrossing:
N.I.
Experimental treatment group (EG):
Hmox-1 -/-
Lethal infection (Con):
no
Lethal infection (EG):
yes
Pathology (Con):
No liverpathology
Pathology (EG):
Liver pathology
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
↑ plasma ALT, similar plasma creatinine and urea, no brain edema; accumulation of plasma protein-bound and non-protein bound heme; ↑ TBARS (lipid peroxidation derivatives in hepatocytes)
Refs:
Seixas et al., 2009, Proc Natl Acad Sci U S A
Hyperlink: