Molecular group:
Neural or endothelial cell stress/damage/activation markers
Molecule/Cell:
HO-1
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^5
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
CO gas
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
No CM
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Protective effect was only seen with early CO treatment; 80 % reduction of BBB disruption; reduced red blood cell and leukocyte sequestration in brain microvasculature; no brain hemorrhages; ↓TNF-a, IFN-g, LT-a, ICAM-1 and VCAM-1 mRNA in brain; ↓CD8+CD69+ T cells, CD8+IFN-g+ T cells, macrophages and PMN recruitment into the brain; restored MetHb concentration; restored plasma free heme concentration to basal levels without inhibition of red blood cell lysis
Refs:
Pamplona et al., 2007, Nat Med
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