Molecular group:
Neural or endothelial cell stress/damage/activation markers
Molecule/Cell:
HO-1
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^5
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
HO-1 inducer
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (10%)
Parasitemia (EG vs Con):
Delayed onset
Additional phenotypes (EG vs Con):
75 % reduction of BBB disruption; no red blood cell and leukocyte sequestration in brain microvasculature; no brain hemorrhages; ↓ plasma free heme concentration
Refs:
Pamplona et al., 2007, Nat Med
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