Molecular group:
Neural or endothelial cell stress/damage/activation markers
Molecule/Cell:
HO-1
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^5
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
HO-1 inhibitor
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (100%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Similar BBB breakdown, microvascular congestion and hemorrhages in brain; similar plasma free heme concentration (increased compared to uninfected C57BL/6 mice)
Refs:
Pamplona et al., 2007, Nat Med
Hyperlink: