Molecular group:
Neural or endothelial cell stress/damage/activation markers
Molecule/Cell:
HO-1
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^5
Mouse genetic background (Con):
BALB/c
Experimental treatment group (EG):
heme
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
No CM
Pathology (EG):
CM (100%)
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
CM symptoms; in vitro data demonstrate that heme in the presence of ROS can disrupt BBB tight junctions
Refs:
Pamplona et al., 2007, Nat Med
Hyperlink: