Molecular group:
Neural or endothelial cell stress/damage/activation markers
Molecule/Cell:
HO-1
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^5
Mouse genetic background (Con):
BALB/c
Experimental treatment group (EG):
HO-1 inhibitor
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
No CM
Pathology (EG):
CM (77.5%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
BBB breakdown; brain hemorrhages; accumulation of activated leukocytes and red blood cells in brain microvasculature
Refs:
Pamplona et al., 2007, Nat Med
Hyperlink: