Molecular group:
Neural or endothelial cell stress/damage/activation markers
Molecule/Cell:
HO-1
Plasmodium strain:
Plasmodium yoelii 17XNL + Salmonella typhimurium
pRBC infection titer:
10^5
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
HO-1 inhibitor
Lethal infection (Con):
yes 100% 18h after S.t. infection
Lethal infection (EG):
yes (20% 18h after S.t. infection
Pathology (Con):
Bacteremia (100%)
Pathology (EG):
Bacteremia (~20%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Infection by P. yoelii XNL decreased resistance against S. typhimurium. HO-1 inhibition restored this resistance and prevented accumulation of S. typhimurium within granulocytes resulting in prolonged survival
Refs:
Cunnington et al., 2012, Nat Med
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