Molecular group:
Leucocyte effector mechanisms and proteases
Molecule/Cell:
caspases
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
5 x 10^4
Mouse genetic background (Con):
C57BL/6J
Experimental treatment group (EG):
caspase inhibitor (ZVAD-fmk)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM(~65 %)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
↓ thrombocytopenia and ↓ microparticles in plasma
Refs:
Piguet et al., 2002, Apoptosis
Hyperlink: