Molecular group:
Neural or endothelial cell stress/damage/activation markers
Molecule/Cell:
PGI2
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
CBA/Ca
Experimental treatment group (EG):
synthetic PGI2 analog
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (75%)
Pathology (EG):
CM (8%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
No neurological symptoms; prolonged survival (~ 2-3 weeks), ↓ serum TNF-a (only 3 mice/group → no statistics performed)
Refs:
Sliwa et al., 1991, Infect Immun
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