Molecular group:
Neural or endothelial cell stress/damage/activation markers
Molecule/Cell:
COX-2
Plasmodium strain:
Plasmodium berghei K173
pRBC infection titer:
10^6
Mouse genetic background (Con):
CBA
Experimental treatment group (EG):
selective COX-2 inhibitor (celecoxib)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
HP&A
Pathology (EG):
HP&A
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
No induction of cerebral symptoms, similar progression of infection
Refs:
Ball et al., 2004, J Infect Dis
Hyperlink: