Molecular group:
Neural or endothelial cell stress/damage/activation markers
Molecule/Cell:
COX-1/2
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
2 x 10^6
Mouse genetic background (Con):
ICR
Experimental treatment group (EG):
COX1/COX2 inhibitor (aspirin)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (85%)
Pathology (EG):
CM (100%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Slightly earlier death; similar mRNA expression of 5-lipoxygenase in brain and spleen; mRNA of phospholipase A2 similar in brain and ↑ on day 12 in spleen; mRNA expression of COX-1 and COX-2 was similar in spleen and ↓ in brain 7 days p.i.; ↑ serum leukotriene B4 levels
Refs:
Xiao et al., 1999, Am J Trop Med Hyg
Hyperlink: