Molecular group:
Angiogenic and coagulation factors
Molecule/Cell:
EPO
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
rHuEpo
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM
Pathology (EG):
less CM
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
Improved survival; reversed clinical symptoms of CM; reduced brain hypoxia
Refs:
Hempel et al., 2011, Am J Pathol
Hyperlink: