Molecular group:
Angiogenic and coagulation factors
Molecule/Cell:
EPO
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^4
Mouse genetic background (Con):
C57BL/6J
Experimental treatment group (EG):
rHuEpo
Lethal infection (Con):
yes
Lethal infection (EG):
% depended on the time and dose of administration
Pathology (Con):
CM (93%)
Pathology (EG):
CM (% depended on the time and dose of administration)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
↑ packed cell volume levels; recovered from hypothermia at the time point when untreated mice succumbed; ↓ IL-1b, TNF, IFN-g and similar caspase-1, caspase-3 and LT mRNA expression in the brain; ↓ number of apoptotic neurons in the brain
Refs:
Wiese et al., 2008, Malar J
Hyperlink: