Molecular group:
Angiogenic and coagulation factors
Molecule/Cell:
EPO
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
CBA/J
Experimental treatment group (EG):
rHuEpo
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (93%)
Pathology (EG):
CM (40%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Similar body weight loss and anemia; ↓ number of ring hemorrhages in the brain; ↓ and delayed TNF and IFN-g and similar caspase-3, caspase-8, TNFR1, TNFR2 and IFN-gR mRNA expression in the brain; similar blood NO levels
Refs:
Kaiser et al., 2006, J Infect Dis
Hyperlink: