Molecular group:
Angiogenic and coagulation factors
Molecule/Cell:
PAFR
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
PAFR selective antagonist (UK74,505)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (40-75%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Recovered from weight loss at the time point when WT mice succumbed
Refs:
Lacerda-Queiroz et al., 2012, Am J Pathol
Hyperlink: