Molecular group:
Angiogenic and coagulation factors
Molecule/Cell:
PAFR
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
PAFR -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (40%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Recovered from weight loss at the time point when WT mice succumbed; ↓ microvascular obstruction; no cerebral hemorrhages; similar leukocyte rolling and adhesion; ↓ pro-IL-1b and CCL2/MCP-1 and similar ICAM-1, VCAM-1, IL-10, CXCL10/IP-10 and CCL5/RANTES mRNA levels in the brain; ↓ brain caspase-3 activation and ↓ caspase-3+ cells; no edema; ↓ CD8+ T cells and less decrease in CD62L on CD8+ T cells
Refs:
Lacerda-Queiroz et al., 2012, Am J Pathol
Hyperlink: