Molecular group:
Angiogenic and coagulation factors
Molecule/Cell:
sFLT1 (sVEGFR)
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6 - 10^7
Mouse genetic background (Con):
DBA/2
Experimental treatment group (EG):
sFLT1-expressing adenovirusses
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
ALI (70%) or HP&A (30%)
Pathology (EG):
ALI (17%) or HP&A (83%)
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
↓ mortality from ALI (18% vs 70%); ↑ sFLT1 expression; ↓ serum VEGF
Refs:
Epiphanio et al., 2010, PLoS Pathog
Hyperlink: