Molecular group:
Angiogenic and coagulation factors
Molecule/Cell:
Fibrinogen
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
5 x 10^5
Mouse genetic background (Con):
CBA/J
Experimental treatment group (EG):
fibrinogen inhibitor
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (100%)
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
Similar thrombocytopenia
Refs:
Senaldi et al., 1998, Cytokine
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