Molecular group:
Angiogenic and coagulation factors
Molecule/Cell:
Plasmin
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6J
Experimental treatment group (EG):
aprotinin (serine protease inhibitor)
Lethal infection (Con):
yes
Lethal infection (EG):
40% (at the end of observation day 15)
Pathology (Con):
CM (100%)
Pathology (EG):
CM (40%)
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
Prolonged survival (until end of observation); ↓ thrombocytopenia
Refs:
Piguet et al., 2000, Infect Immun
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