Molecular group:
Angiogenic and coagulation factors
Molecule/Cell:
Urokinase plasminogen activator (uPA)
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6 x 129/Sv
Level of backcrossing:
Mixed background (50%)
Experimental treatment group (EG):
uPA -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (90%)
Pathology (EG):
CM (30%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Prolonged survival (~1 week); ↓ thrombocytopenia
Refs:
Piguet et al., 2000, Infect Immun
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