Molecular group:
Leucocyte effector mechanisms and proteases
Molecule/Cell:
MMP/TACE
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^4
Mouse genetic background (Con):
C57BL/6J
Experimental treatment group (EG):
Broad-spectrum MMP/TACE inhibitor
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (100%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Mice died 1 day later
Refs:
Van den Steen et al., 2006, Lab Invest
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