Molecular group:
Leucocyte effector mechanisms and proteases
Molecule/Cell:
Histamine R3/R2
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
H3R -/-
Level of backcrossing:
N.I.
Experimental treatment group (EG):
H2R inhibitor (cimetidine)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (60%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
↓ IFN-g and TNF-a brain mRNA expression 6 days p.i.
Refs:
Beghdadi et al., 2009, PLoS One
Hyperlink: