Molecular group:
Leucocyte effector mechanisms and proteases
Molecule/Cell:
Histamine R1
Plasmodium strain:
Plasmodium berghei NK65
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
H1R inhibitor (levocetirizine)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Prolonged survival (~3 days)
Refs:
Beghdadi et al., 2008, J Exp Med
Hyperlink: