Molecular group:
Leucocyte effector mechanisms and proteases
Molecule/Cell:
Histamine R1
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6J
Experimental treatment group (EG):
H1R inhibitor (levocetirizine)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (80%)
Pathology (EG):
CM (30%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Prolonged survival (2-3 weeks) only when used prophylactic; ↓ IFN-g and TNF-a brain mRNA expression 6 days p.i.
Refs:
Beghdadi et al., 2009, PLoS One
Hyperlink: