Molecular group:
Leucocyte effector mechanisms and proteases
Molecule/Cell:
Histidine decarboxylase (HDC)/CD4
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
HDC -/-
Level of backcrossing:
Pure strain (100%)
Experimental treatment group (EG):
anti-CD4
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
No CM
Pathology (EG):
No CM
Parasitemia (EG vs Con):
Increased
Additional phenotypes (EG vs Con):
Prolonged survival (2-3 weeks)
Refs:
Beghdadi et al., 2008, J Exp Med
Hyperlink: