Molecular group:
Leucocyte effector mechanisms and proteases
Molecule/Cell:
Histidine decarboxylase (HDC)
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Pure strain (100%)
Experimental treatment group (EG):
HDC -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
No CM
Parasitemia (EG vs Con):
Decreased on day 9
Additional phenotypes (EG vs Con):
Prolonged survival (~2 weeks); no neurological symptoms; ↓ pRBC aggregates, CD4+ T cells, CD8+ T cells and ICAM-1 expression in brain microvessels; ↓ ICAM-1, IL-10, IFN-g and IL-5 mRNA, ↑ VCAM-1 mRNA and unsignificant ↓ IL-4 mRNA expression in the brain; ↓ serum IFN-g, KC and IL-5; similar serum TNF-a, IL-10, and MIP-1a; unsignificant ↓ in serum IL-6 and MCP-1; similar CD8 OT-1 and CD4 OT-2 proliferative responses after treatment with OVA
Refs:
Beghdadi et al., 2008, J Exp Med
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