Molecular group:
Leucocyte effector mechanisms and proteases
Molecule/Cell:
Perforin (PFP)
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
N.I.
Level of backcrossing:
N.I.
Experimental treatment group (EG):
PFP -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM
Pathology (EG):
No CM
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
No brain edema or hemorrhages; similar sequestration of leukocytes in brain microvasculature; similar endothelial staining of fibrinogen but no leakage of fibrinogen in brain parenchyma; ↓ mRNA expression of granzyme B, ↑ mRNA expression of CD8 and similar mRNA expression of CD4 (no increase) in brain; no TUNEL/isolectin double positive cells in retinae
Refs:
Potter et al., 2006, Int J Parasitol
Hyperlink: