Molecular group:
Leucocyte effector mechanisms and proteases
Molecule/Cell:
Perforin (PFP)
Plasmodium strain:
Plasmodium berghei NK65
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
PFP -/-
Lethal infection (Con):
yes
Lethal infection (EG):
N.I.
Pathology (Con):
Liver pathology
Pathology (EG):
No liverpathology
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
↓ serum GPT (ALT); no liver injury; similar lymphocyte infiltration in liver
Refs:
Adachi et al., 2001, J Immunol
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