Molecular group:
Leucocyte effector mechanisms and proteases
Molecule/Cell:
FasL
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6 for WT, N.I. for Gld
Level of backcrossing:
N.I.
Experimental treatment group (EG):
FasL -/- (gld)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM
Pathology (EG):
resolving CM and died from HP&A
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Mice displayed all the cerebral symptoms of CM around day 6-8 (hemorrhages, edema, leukocyte sequestration), but recovered from all the symptoms and died later of overwhelming parasitemia; similar splenomegaly; deposits of hemozoin in the brain parenchyma presumably from previous hemorrhages or pRBC sequestration; similar CD8 and CD4 mRNA expression in spleen and similar CD8, CD4, TNF-a, perforin and granzyme B mRNA expression in brain; no apoptotic astrocytes in retinal wholemount tissue (IHC)
Refs:
Potter et al., 2006, J Neuroimmunol
Hyperlink: