FasL

Molecular group: 
Leucocyte effector mechanisms and proteases
Molecule/Cell: 
FasL
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
10^6
Mouse genetic background (Con): 
C57BL/6 for WT, N.I. for Gld
Level of backcrossing: 
N.I.
Experimental treatment group (EG): 
FasL -/- (gld)
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
CM
Pathology (EG): 
resolving CM and died from HP&A
Parasitemia (EG vs Con): 
Similar
Additional phenotypes (EG vs Con): 
Mice displayed all the cerebral symptoms of CM around day 6-8 (hemorrhages, edema, leukocyte sequestration), but recovered from all the symptoms and died later of overwhelming parasitemia; similar splenomegaly; deposits of hemozoin in the brain parenchyma presumably from previous hemorrhages or pRBC sequestration; similar CD8 and CD4 mRNA expression in spleen and similar CD8, CD4, TNF-a, perforin and granzyme B mRNA expression in brain; no apoptotic astrocytes in retinal wholemount tissue (IHC)
Refs: 
Potter et al., 2006, J Neuroimmunol