Molecular group:
Leucocyte effector mechanisms and proteases
Molecule/Cell:
Fas
Plasmodium strain:
Plasmodium berghei NK65
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
Fas -/- (lpr)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
Liver pathology
Pathology (EG):
Liver pathology
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
Similar serum GPT (ALT), liver injury and lymphocyte infiltration in liver
Refs:
Adachi et al., 2001, J Immunol
Hyperlink: