Molecular group:
Leucocyte effector mechanisms and proteases
Molecule/Cell:
Fas
Plasmodium strain:
Plasmodium berghei K173
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6 for WT, N.I. for Lpr
Level of backcrossing:
N.I.
Experimental treatment group (EG):
Fas -/- (lpr)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
HP&A
Pathology (EG):
HP&A
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Similar hematocrit and splenomegaly, no cerebral pathology (similar to WT mice)
Refs:
Potter et al., 2006, J Neuroimmunol
Hyperlink: