Molecular group:
Other leucocyte cell surface receptors and membrane transporters
Molecule/Cell:
FcgRIIB/TLR7
Plasmodium strain:
Plasmodium yoelii 17XL
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
FcgRIIB-/-.yaa (SLE-susceptible), contains a duplication of TLR7
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
HP&A
Pathology (EG):
HP&A
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Similar mortality; ↑ splenomegaly; ↓ brain and similar kidney weight
Refs:
Waisberg et al., 2010, Proc Natl Acad Sci U S A
Hyperlink: