Molecular group:
Other leucocyte cell surface receptors and membrane transporters
Molecule/Cell:
FcgRIIB/TLR7
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
FcgRIIB-/-.yaa (SLE-susceptible), contains a duplication of TLR7
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (90%)
Pathology (EG):
CM (10%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Prolonged survival (~1 week); ↑ splenomegaly 7 days p.i.; ↓ postmortem brain and similar kidney weight; developped moderated kidney inflammation; ↓ number of brain microhemorrhages; ↑ serum GM-CSF and IL-10 before infection; similar levels of serum GM-CSF and ↓ IL-10, IFN-g, IL-12p70, IL-17, IL-6, MCP-1 and RANTES 5 days p.i.; splenic immune cell populations had features of a controlled chronic activation before infection that was absent in WT mice, and infection resulted in ↓ inflammatory responses compared to WT mice; similar recruitment of CD4+ and CD8+ T cells with a similar activation status in the brain
Refs:
Waisberg et al., 2010, Proc Natl Acad Sci U S A
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