Molecular group:
Other leucocyte cell surface receptors and membrane transporters
Molecule/Cell:
FcgR
Plasmodium strain:
Plasmodium yoelii 17XL
pRBC infection titer:
10^4
Mouse genetic background (Con):
BALB/cByJ
Level of backcrossing:
Backcrossed for 12 generations
Experimental treatment group (EG):
FcRg -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Passive transfer of hyperimmune mice sera protected equally
Refs:
Rotman et al., 1998, J Immunol
Hyperlink: