Molecular group:
Other leucocyte cell surface receptors and membrane transporters
Molecule/Cell:
FcgR
Plasmodium strain:
Plasmodium berghei XAT
pRBC infection titer:
10^4
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for 6 generations
Experimental treatment group (EG):
FcRg -/-
Lethal infection (Con):
no
Lethal infection (EG):
yes
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
No parasite clearance
Additional phenotypes (EG vs Con):
↓ phagocytic activity by splenic macrophages; similar IFN-g production by spleen cells; similar total IgG, IgG1, IgG2a, IgG2b and IgG3; passive transfer of anti-XAT IgG failed to suppress the increase in parasitemia
Refs:
Yoneto et al., 2001, J Immunol
Hyperlink: