FcgR

Molecular group: 
Other leucocyte cell surface receptors and membrane transporters
Molecule/Cell: 
FcgR
Plasmodium strain: 
Plasmodium berghei XAT
pRBC infection titer: 
10^4
Mouse genetic background (Con): 
C57BL/6
Level of backcrossing: 
Backcrossed for 6 generations
Experimental treatment group (EG): 
FcRg -/-
Lethal infection (Con): 
no
Lethal infection (EG): 
yes
Pathology (Con): 
N.I.
Pathology (EG): 
N.I.
Parasitemia (EG vs Con): 
No parasite clearance
Additional phenotypes (EG vs Con): 
↓ phagocytic activity by splenic macrophages; similar IFN-g production by spleen cells; similar total IgG, IgG1, IgG2a, IgG2b and IgG3; passive transfer of anti-XAT IgG failed to suppress the increase in parasitemia
Refs: 
Yoneto et al., 2001, J Immunol