Molecular group:
Other leucocyte cell surface receptors and membrane transporters
Molecule/Cell:
CTLA-4/CD4
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^4
Mouse genetic background (Con):
BALB/cAnNCrl
Experimental treatment group (EG):
anti-CTLA-4 + anti-CD4
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (~30%)
Pathology (EG):
CM (% depended on the time of administration)
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
Early CD4 depletion delayed the onset of CM
Refs:
Hafalla et al., 2012, PLoS Pathog
Hyperlink: