Molecular group:
Other leucocyte cell surface receptors and membrane transporters
Molecule/Cell:
CTLA-4
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^4
Mouse genetic background (Con):
BALB/cAnNCrl
Experimental treatment group (EG):
anti-CTLA-4
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (~30%)
Pathology (EG):
CM (100%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
↑ numbers of CD8+ T cells in the brain; ↑ frequency of brain petechial hemorrhages; ↑ proportion of vessels plugged with iRBCs; ↑ numbers of pigmented (parasite-containing) macrophages in the liver; ↑ whole body, head and isolated brain parasite burdens (↑ bioluminescence of luciferase-expressing parasites); ↑ proportion of activated CD4+ and CD8+ T cells in the spleen; ↑ plasma IFN-g, TNF, IL-6, IL-10 and MCP-1/CCL2; ↑ secretion of IFN-g and IL-10 by stimulated CD4+ T cells and ↑ IFN-g secretion by stimulated CD8+ T cells;
Refs:
Hafalla et al., 2012, PLoS Pathog
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