Molecular group:
Other leucocyte cell surface receptors and membrane transporters
Molecule/Cell:
CTLA-4
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^5
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
anti-CTLA-4
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
Moderate liver pathology
Pathology (EG):
↑ Liver pathology
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
↑ serum ALT and AST; ↑ weight loss; ↑ CD4+ and CD8+ T cells and similar gd T cells in liver parenchyma 8 days p.i.; ↑ and similar number of IFN-g producing cells in liver and spleen, respectively; similar and ↑ proliferation of liver and spleen cells, respectively
Refs:
Jacobs et al., 2004, Eur J Immunol
Hyperlink: