Molecular group:
Other leucocyte cell surface receptors and membrane transporters
Molecule/Cell:
CTLA-4
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^5
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
anti-CTLA-4
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
No CM
Pathology (EG):
CM (100%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Earlier death (~2 weeks); ↑ weight loss; induction of neurological symptoms; no ↓ CD4+ T cells in spleen 5 days p.i.; ↑ spontaneous and anti-CD3 induced proliferation of spleen cells taken on day 5 p.i. But not from day 8 p.i.; similar IFN-g and ↑ NO production by anti-CD3 stimulated spleen cells 8 days p.i.; ↑ pathology and hemozoin deposition in liver
Refs:
Jacobs et al., 2002, J Immunol
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