Molecular group:
Other leucocyte cell surface receptors and membrane transporters
Molecule/Cell:
CTLA-4
Plasmodium strain:
Plasmodium yoelii 17XL
pRBC infection titer:
5 x 10^6
Mouse genetic background (Con):
BALB/c
Experimental treatment group (EG):
anti-CTLA-4 (day 0)
Lethal infection (Con):
30%
Lethal infection (EG):
70%
Pathology (Con):
N.I.
Pathology (EG):
Liver pathology
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
↑ serum ALT and AST levels (↑ liver pathology); ↑ weight loss; ↑ % CD25+ CD4+, CD62Llow CD4+ and CD69+ CD4+ T cells in spleen; similar IL-12p40 and ↑ IFN-g, TNF-a, IL-4 and IL-10 in serum
Refs:
Lepenies et al., 2007, Microbes Infect
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